Publications on Rauwolfia vomitoria
Interested in a specific ingredient perfected by Dr. Beljanski? For your convenience we have selected on one page all the scientific publications published by Dr. Beljanski on this specific ingredient, as well as the research papers resulting from the Beljanski Foundation’s partnerships. The goal of the Foundation is to share this knowledge and increase awareness about scientific research conducted on natural compounds. If you care about providing scientifically researched alternatives to chemical drugs, please support the Beljanski Foundation’s research program.
We investigated Rauwolfia vomitoria extract as a therapeutic option for benign prostatic hyperplasia, a common disease in older men with serious impact on quality of life. The oral administration of the Rauwolfia extract significantly reduced prostate weight in animals with BPH, which is shown by the decreased thickness of the prostate epithelial layer. Similar effects were observed in the BPH animals treated with finasteride. The Rauwolfia extract significantly reduced the level of androgen receptor and 5 alpha reductase as well as testosterone-induced proliferation markers — Proliferating cell nuclear antigen (PCNA) and Cyclin D1. As evidence of its lack of side effects, Rauwolfia did not reduce sperm counts whereas Finasteride did.
The poor treatment outcomes of pancreatic cancer are linked to an enrichment of cancer stem cells (CSCs) in these tumors, which are resistant to chemotherapy and promote metastasis and tumor recurrence. In these experiments, the pancreatic CSC population, identified using cell surface markers or a tumor spheroid formation assay, was significantly reduced by the Rauwolfia vomitoria extract. In vivo the Rauwolfia extract significantly reduced the tumorigenicity of pancreatic cancer cells. Taken together, these data showed that Rauwolfia preferentially inhibited pancreatic cancer stem cells.
Cancer stem cells are a type of stem cell specific to cancer, that is able to reproduce through self-renewal and regeneration into new tumor cells. Cancer stem cells are thought to survive chemotherapy treatments and provide the basis for tumor regrowth. It is critical to find treatments for cancer stem cells to prevent this disease from resurfacing in a person again and again. Research conducted at Kansas University Medical Center concluded that both the Pao pereira (Pau pereira) and Rauwolfia vomitoria extracts inhibited the proliferation of multiple human ovarian cancer cell lines in vitro.
Research conducted at the University of Kansas Medical Center concluded that Rauwolfia vomitoria was effective against ovarian cancer cells both alone and in combination with carboplatin. The combination decreased tumor size in animal experiments by 87 to 90%. The authors conclude that, “Rauwolfia vomitoria has potent antitumor activity and in combination significantly enhances the effect of carboplatin against ovarian cancer.”
In preclinical pancreatic cancer models, Rauwolfia vomitoria extract induced apoptosis in pancreatic cancer cells in a dose-dependent manner. The combination of Rauwolfia extract and gemcitabine had a synergistic effect in inhibiting cell growth. Pancreatic tumor growth was significantly suppressed by Rauwolfia treatment and metastasis was inhibited as well. Adding Rauwolfia extract to gemcitabine treatment further reduced tumor burden and metastatic potential in the gemcitabine resistant tumors. These data suggest that Rau possesses anti–pancreatic cancer activity and could improve the effect of gemcitabine.
Dr. Mirko Beljanski's Publications
As he was developing his extracts Dr. Mirko Beljanski referred to Pao Pereira as PB100, Rauwolfia Vomitoria as BG-8, Gingko Biloba as Bioparyl and RNA fragments as R.L.B.
Médecines nouvelles, 15, 1986, pp. 57-86.
Deutsche Zeitschrift für Onkologie 5, 22, 1990, pp. 145-152.
Available in French only.
ABSTRACT: La sélectivité d’action des substances est une notion aussi nouvelle que fondamentale. Alors que toutes les autres solutions jusqu’ici offertes sont brutales, toxiques (les médicaments s’incorporant souvent sans retour dans les gènes), est offert une alternative ciblée, de toute sécurité, multifocale afin que le virus soit détruit, l’immunité protégée et l’équilibre rétabli, seules conditions pour une vie de qualité se dirigeant jour après jour vers la “guérison”..
ABSTRACT: When past the stage amenable to surgery, melanoma and its metastases are, as a rule, treated with chemotherapy, which is largely unsuccessful. In this report, experimental evidence is presented demonstrating that, in vitro, two selective anticancer agents, PB-100 and BG-8, dose dependently destroy human G-361 melanoma cells, but do not affect human non malignant CCD-974Sk fibroblasts used as controls. Trace metal compounds, present, often in abnormal amounts, in the cancer cell and/or its environment, are known to influence its proliferation. Assays were carried out using highly elevated amounts of ferritin, iron chloride or zinc chloride. Ferritin proved differentially mitogenic for melanoma cells and fibroblasts. Its activity was inhibited by both anticancer agents, which however tended to become less efficacious in its presence. FeCl3 was more moderately, but equally, mitogenic for malignant and normal cells, yet it impaired antiproliferative activity of PB-100 and inhibited that of BG-8. ZnCl2 exhibited a selective antiproliferative activity on the malignant melanoma cells; it did not compete with PB-100 or BG-8. Specific recognition and destruction of malignant cells by the two anticancer agents are discussed.
