Pao pereira
(Geissospermum vellosii or Geissospermum leave velloso) also known as Pau pereira


Pao pereira (Geissospermum vellosii, or Geissospermum leave velloso), also spelled Pau pereira, is a well-known tree, native to South America. This plant, which has been used in traditional medicine for centuries to fight malaria and tropical fevers, is also very much a part of South American popular culture. Learn more

Dr. Mirko Beljanski (1923-1998) discovered that a flavopereirine-rich Pao pereira extract was an effective destroyer of cancer cells, without harming healthy cells. Pao pereira has also been shown to have antiviral activity.

Recent breakthroughs in Cancer with Pao pereira (Pau pereira)


Dr. Beljanski observed that the DNA double helix in cancer is permanently destabilized, whereas, in normal DNA, relaxation only occurs locally and temporarily for replication or for gene expression. Dr. Beljanski perfected two natural extracts, Pao pereira and Rauwolfia vomitoria, that selectively bind to the destabilized DNA in cancer cells, impede DNA synthesis and induce cancer cell death by apoptosis or cell cycle arrest. Working at the level of the DNA, the Pao pereira extract is not organ or gender specific.


Dr. Beljanski showed that combining his extracts with chemotherapy drugs could improve conventional cancer treatments. Recent research at Kansas University Medical Center has confirmed the synergy of these combinations. The extract enables lower doses of the anti-cancer drugs to be used while maintaining the same anti-tumor effect and reducing the toxicity and negative side effects associated with the drugs. The extract plus drug combinations are even effective against tumor cells that have become resistant to the chemotherapy drug being used.


There are reports of Pao pereira’s effectiveness against numerous viruses including herpes, hepatitis, HIV, Epstein-Barr virus and SARS CoV-2 (COVID-19). The extract inhibits viral polymerases including reverse transcriptase by binding to the viral genome and blocking progression of the enzyme so viral genome replication fails and new viruses are not produced.


Benign Prostatic Hyperplasia (BPH), which has been linked to prostate cancer risk, involves DNA changes in tissues. Pao pereira and Rauwolfia vomitoria extracts have shown potential against cancer by targeting this damaged DNA. Recent studies highlight their effectiveness in reducing BPH in animal models by correcting androgen imbalance, shrinking the prostate, and combating inflammation, suggesting BPH's reversibility.

comparative study of Pao Pereira conducted by The Beljanski Foundation showed that the concentration of this alkaloid can vary dramatically from one preparation to another.

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Promising Results: Efficacy Of Two Plant Extracts For Benign Prostatic Hyperplasia (BPH)

John Hall and Sylvie Beljanski

The prostate gland is a major source of serious health problems for men. It is susceptible to the most common chronic inflammatory condition, benign prostatic hyperplasia (BPH), and prostate cancer is the most common malignancy. Age significantly increases the risk for both, but lifestyle factors such as diet, physical activity, and toxin exposure also play roles. BPH often results from hormonal shifts in aging men, while genetics can influence prostate cancer risk.

BPH can lead to prostate cancer due to chronic inflammation and specific DNA changes within BPH tissues, highlighting a molecular link between these conditions. At the molecular level, research has found that two plant extracts, Pao pereira and Rauwolfia vomitoria, can target and repair this DNA damage, triggering cell death in cancerous cells. This mechanism shows promise in treating both prostate cancer and BPH.

Recent research from Dr. Jun Yan’s laboratory at Nanjing University, sponsored by the Beljanski Foundation, shows that both extracts are also remarkably effective for BPH in an animal model: the androgen imbalance seen in older men is corrected, the prostate is reduced to normal size, and the inflammatory condition is directly suppressed [6-9]. The effects of the extracts demonstrate that BPH is reversible.

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pao pereira

Pao pereira
And Its Effectiveness With Different Cancers

Since 1999, The Beljanski Foundation has worked toward curing cancer the natural way. The primary focus has been the anti-cancer and anti-inflammatory action of the Pao pereira and Rauwolfia vomitoria plant extracts developed by Dr. Mirko Beljanski.

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Mirko Beljanski and the Anti-Cancer Activity of the
Pao Pereira Extract

Dr. Beljanski is best known for his anti-cancer extracts, Pao pereira and Rauwolfia vomitoria, because of their broad spectrum and non-toxic anti-cancer effect. The Foundation’s more recent research has demonstrated that they are also effective against all stages of cancer including precancerous chronic inflammatory conditions, early and mid-stage cancers, as well advanced and metastatic disease. The studies demonstrating anti-cancer stem cell activity mean that the extracts are effective in preventing cancer recurrence. And due to the absence of side effects these extracts can be used aggressively when needed.

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"The research work of Mirko Beljanski led to the development of nutritional supplements that are potentially beneficial to cancer patients, either alone or in combination with anti-cancer activity."

Dr. Michael B. Schacter, MD, CNS

Director of the Schachter Center for Complementary Medicine

How it works

The Pao pereira and Rauwolfia vomitoria extracts target destabilized DNA, which is characteristic of all cancer cells of all types. By binding specifically to the damaged DNA structure in cancer cells the extracts disable the process of DNA replication which prevents cell division and leads to cancer cell death. The normal process of DNA replication and cell division in healthy cells is unaffected so the extracts are nontoxic.


Research has demonstrated that flavopereirine, Pao pereira’s active molecule, exhibits numerous mechanisms of action that cumulatively explain the multiple benefits of Beljanski’s extract. In cancer cells, flavopereirine works by binding specifically to the damaged DNA structure and preventing DNA replication which leads to cancer cell death by apoptosis or cell cycle arrest. This effect has been established in prostate, ovarian and pancreatic cancer cells.  Flavopereirine has also been shown to induce apoptosis in colorectal cancer cells. Learn more

In advanced prostate cancer Pao pereira (Pau pereira) inhibits the NFκB signaling pathway suppressing survival, proliferation and metastasis of the cancer cells. In BPH, Pao pereira (Pau pereira) also targets NFκB resulting in a direct suppression of pro-inflammatory signals. Learn more

The extract is also effective at destroying the cancer stem cells responsible for metastasis and recurrence. Here again, the mechanism is induction of apoptosis as well as inhibition of Wnt/β-catenin signaling.


HIV infected patients treated with Pao pereira were followed for a full year. The results were published in 1994. The results confirmed the safety of the extract, the improvement of lymphocyte subpopulations (T4 / T8 ratio), and several other positive indications. During this trial, patients did not progress to full AIDS and did not develop opportunistic diseases so common with other therapies. Learn more

What it says about Pao Pereira

Dr. de Kuyper was quick to oblige. When he arrived at the Elysée Palace, French President Mitterrand was lying in his bed.

“What can you do for me? Help me suffer less? Help me die peacefully?”

“I think we can do better than that Mr. President. Based on my experience and if you are serious about taking the pills I am going to prescribe you, I think we can not only slow down the progression of the disease, but we can reasonably hope to get you back on your feet.”

“Nothing would be more important to me than to finish my work.”

So, Mitterrand began taking the Pao pereira and the Rauwolfia vomitoria extracts. Against all odds, he started to get better.

P.13 Winning The War On Cancer: The Epic Journey Towards a Natural Cure

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Survivor stories

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