BPH

Benign Prostatic Hyperplasia (BPH)

Benign Prostatic Hyperplasia (BPH) is the most common inflammatory condition in men, especially older men. It affects over 15 million men in the US and tens of millions more worldwide. It is characterized by progressive enlargement of prostate tissues leading to constriction of the urethra and urinary problems that can be severe. BPH creates quality of life issues for men and increases the risk of prostate cancer. Two major classes of drugs, 5α-reductase inhibitors and α-blockers, are  prescribed to treat BPH, but these drugs are associated with various unpleasant side effects.

Studies from Nanjing University show that the Pao pereira and Rauwolfia vomitoria plant extracts, which possess antiproliferative activity against various human cancer cells, including prostate cancer cells, also demonstrate excellent anti-BPH effects comparable to the drugs, but without the negative side effects.

Recent breakthrough in BPH

A paper published in the December 2020 issue of the Journal of Integrative Medicine shows that the Rauwolfia vomitoria plant extract reverses the prostate enlargement associated with BPH and alleviates the troublesome symptoms of this condition. The extract works by restoring hormone and androgen receptor balance and is effective for both treatment and prevention of BPH. The plant extract is just as effective at reducing prostate size as the commonly used drug finasteride, but side effects of the drug, like reduced sperm counts, were not observed with the extract.

ANDROGEN BALANCE IN BPH

The key BPH-associated enzyme, 5α-reductase, which converts testosterone into its more aggressive form dihydrotestosterone (DHT), is inhibited by the Rauwolfia vomitoria extract. The extract also reduces the level of androgen receptor (AR). Since the binding of DHT to AR is what drives prostate cell growth, the extract removes the trigger for BPH. The Pao pereira extract has the very same hormone balancing effect.

NFKB IN BPH

BPH is also fostered by NFκB signaling which leads to release of pro-inflammatory chemokines. By inhibiting NFκB activation, the Pao pereira extract suppresses these chemokines while inducing apoptosis in BPH cells.   Previous work from Nanjing University showed that Pao pereira extract inhibits NFκB signaling in advanced prostate cancer cells. The Pao pereira extract offers safe anti-inflammation and anti-cancer activity for the prostate.

NFKB IN INFLAMMATION AND CANCER

The inhibition of NFκB signaling by Pao pereira extract has potential that goes beyond prostate inflammation and prostate cancer. NfκB is a control center that regulates inflammation and cancer in many types of cells and the Pao extract offers inhibition consistent with normal physiology. We expect the extract to be effective in other cases of inflammation associated cancers such as triple negative breast cancer.

Publications


columbia university medical center research about prostate cancer

What if the same approach could offer both prevention and intervention? What if this approach was effective and devoid of side effects?

Over 40 million men suffer from BPH in the United States alone and conventional medicine  does not offer a definitive cure without side effects. Recent research shows that Pao pereira (Pau pereira) extract reduces chronic prostate inflammation by balancing the hormone changes that occur with age and inhibiting excess NFkB activity that promotes prostate inflammation. In addition, Pao pereira (Pau pereira) induces apoptosis, also known as the “cell death program”, of those cells which are chronically inflamed. These BPH studies complement previous publications showing that Pao pereira (Pau pereira) is effective on prostate cancer cells and even on metastasized cancer cells that no longer respond to hormonal treatments. Both Pao pereira (Pau pereira) and Rauwolfia vomitoria, selectively block the duplication of cancerous destabilized DNA while not affecting healthy DNA.

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The Beljanski Approach to Cancer

Now there’s a natural way to combat cancerous cells while being gentle on healthy cells. Dr. Mirko Beljanski, PhD., now being recognized as the “Father of Environmental Medicine,” conducted ground-breaking research revealing the connection between toxins in our environment and the onset of cancer. And he was quick to reason that nature holds the answers for a cure to all cancers. Natural, non-toxic ingredients developed and perfected by Dr. Mirko Beljanski selectively block the duplication of cancerous destabilized DNA while not affecting healthy DNA. They work on every type of cancer at every stage because they are not gender or organ specific. Based upon the legacy of Dr. Mirko Beljanski, the Beljanski Foundation has been working collaboratively for the past three decades with scientists worldwide to research a natural approach to cancer.

The Beljanski extracts have now become the topic of many peer-reviewed scientific publications, from numerous academic institutions, confirming their effectiveness and providing a deeper understanding of their mechanism of action.

The Beljanski Foundation’s team is committed to sharing these findings with you, so that you can make informed decisions to help restore and maintain optimal health.

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"Men are clearly having less frequency, better streams, and better flow rates. They are not getting up as often at night. The bottom line is that our early results are very encouraging regarding Beljanski’s extracts’ ability to lower PSA and also help older men urinate better."

Dr. Andy. Katz, “The Columbia Connection.” The Doctors’ Prescription for Healthy Living 14, no. 8, September 2010, 27.

What it says about BPH

“At the restaurant, Dr. Katz greeted me with his trademark flashy grin. Despite my anxiety I smiled back. He reiterated his enthusiasm for the safety and efficacy displayed by both extracts in the initial studies. Having shown that tumor growth was suppressed by up to 80 percent in mice grafted with prostate tumor cells and with no signs of toxicity, Dr. Katz was now ready to run a clinical trial on men with an elevated PSA reading. He would give them a special combination of both Pao pereira and Rauwolfia Vomitoria. Indeed, whenever two anticancer agents work by different mechanisms of action, it makes sense to use them together. This approach takes advantage of the potential for a synergistic effect, especially considering that there are not many treatment options currently offered to men with elevated PSA. Typically, such patients are put on regular observation of their condition, waiting for the time when conventional treatment (radiation, chemotherapy and surgery) becomes necessary.”

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Publications BPH

Publications on BPH


Pao Pereira extract suppresses benign prostatic hyperplasia by inhibiting inflammation-associated NFκB signaling


Benign prostatic hyperplasia (BPH) is a non-malignant enlargement of the prostate gland, common in older males, that causes urinary and quality of life problems. In a previous study we found that the Pao pereira extract can attenuate BPH development in a rat model by reducing expression of androgen receptor and 5α-reductase. In this study we looked further into the molecular mechanism of Pao pereira’s anti-inflammatory effect in BPH. We found the Pao extract suppressed the growth of two BPH cell lines: BPH-1 and WPMY-1 by inducing apoptosis via inhibition of the NFκB signaling pathway. These findings suggest that Pao Pereira extract may be a very promising therapeutic for BPH.

Rauwolfia Vomitoria Extract Suppresses Benign Prostatic Hyperplasia (BPH)


We investigated Rauwolfia vomitoria extract as a therapeutic option for benign prostatic hyperplasia, a common disease in older men with serious impact on quality of life. The oral administration of the Rauwolfia extract significantly reduced prostate weight in animals with BPH, which is shown by the decreased thickness of the prostate epithelial layer. Similar effects were observed in the BPH animals treated with finasteride. The Rauwolfia extract significantly reduced the level of androgen receptor and 5 alpha reductase as well as testosterone-induced proliferation markers — Proliferating cell nuclear antigen (PCNA) and Cyclin D1. As evidence of its lack of side effects, Rauwolfia did not reduce sperm counts whereas Finasteride did.

Marcel foundation cancer testimonial headshot

Marcel Hamon: Prostate Cancer

7 years of hindsight.

June to October 2011: construction of a small vacation house to visit North America (the trip of my dreams). Life is Beautiful.

March 2012: Everything is ready for departure: boarding of the vehicle on April 8 in Antwerp. At the beginning of the month, last medical check before departure: PSA level 6.41 ng / l and normal ultrasound (no tumor).

In mid-March, my attending physician went on an internship on undetectable cancers of the prostate. Back from training, she calls me in for a biopsy.

She has to tap into her pitch to convince me to do it.

We are 3 weeks before departure. The biopsy was performed on March 22, 2012. We had the results on April 2: the right lobe of the prostate was completely affected (9 out of 9 samples were positive) with Gleason index cancer (4 + 3).

Catastrophe > life changes, we are crushed, the trip is canceled.

We go from doctor to doctor and search the internet. One night, my wife thinks of François Mitterrand and his prostate cancer.

She gets up and searches the google. We discover the Beljanski Foundation. The following day, we phoned the foundation and then Maison Beljanski in New York to order the extracts: Pao pereria and Rauwolfia vomitoria. The medical visits continue as I got an MRI in St. Nazaire, on May 9 > the cancer crossed the prostate wall (we are panicked); on May 13, bone scintigraphy in Nantes > good news: no damage to the skeleton.

During our visits to the doctor, we confirmed I would get prostate surgery. We must first go through the oncology consultation meeting in St. Nazaire which, for a prostatic adenocarcinoma classified T2NX Mo Gleason 4 + 3, but probably a T3 classification on the right, suggests:

  • Standard treatment:
    Hormone therapy and Radiotherapy.
  • Optional treatment:
    Surgery with lymph node dissection > depending on the result, additional postoperative radiotherapy will probably be necessary.

Obviously, I am taking the optional treatment (the operation) with the Beljanski treatment in secret. On June 18, 2012, I had an operation and have been on Pao V FM® (Pao pereria) and Rovol (Rauwolfia vomitoria) for 20 days.

Following the operation, I have a nosocomial infection and I remain hospitalized for 11 days instead of the 4 planned (result: weight loss = 7Kg).

During a visit, the surgeon informs me that the removed lump has been analyzed and that unfortunately radiation therapy will be necessary.

I continue the Beljanski treatment. At the end of July, the first blood test after the operation gave a PSA of 0.03ng / l. The surgeon is surprised: he expected a rate greater than 0.7ng / l.

He suggested that I join a study (Gétug 17: radiotherapy and hormone therapy with Decapeptyl LP). I refuse in view of my PSA level. On October 23, 2012, I have an appointment with the Nantes oncologist.

In the waiting room, he tells me that he begins with information before the consultation.
I give him my last PSA rate = 0.04ng / l. He is surprised and tells me that, in my case, French researchers are trying a new treatment...

I recognized Getug 17. I tell him and confirm my opposition. Immediately he gets up and I won't have a look. Since then, I have continued the Beljanski treatment.

I made my dream come true: 18 months in North America. Beljanski products have been delivered to me across Canada and the U.S.A. without a problem.

I live normally but I am more careful with my diet now (almost vegetarian) and stopped drinking alcohol. The last PSA rate was done in Mexico: 0.04ng / l. We go home and in May 2015, the rate suddenly increased: 0.08ng / l. We asked ourselves a lot of questions.

Recurrence: The examinations start again: scanner, MRI, scintigraphy. In the meantime, I have changed doctors. The scan showed that the bones were not affected. The oncologist gives me Fluorocholine (positron emission tomography) to target very precisely the areas of recurrence.

The result shows that the 2 positive margins on the urethra, which are not vascularized, generated cancer cells in the pelvic lymph nodes.

The only treatment offered is a study: the Getug P07 protocol (6-month hormone therapy and radiotherapy with a maximum of 74Gy: 37 sessions).

The sessions were carried out between October 1 and the end of November. I had some side effects.

Secondary: drop in white blood cells and joint pain. I continued the Beljanski treatment throughout the treatment adding Ginkgo for the effects of the radiotherapy.

The drop in white blood cells is due to radiation therapy near the pelvis. To overcome this problem, I did a treatment with RNA fragments (RealBuild®).

My PSA rate between January 2016 and December 2018 is 0.00ng / l.

I continue the Beljanski products as a 2-month treatment with a 3-month break. Still having a problem with white blood cells (due to radiotherapy to the pelvis), I take RNA Fragments all winter long.

Thank you Beljanski Foundation for listening to me. Thank you to the doctors who support my decision to use the Beljanski extracts.


Pao Pereira Extract Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by inhibiting 5α-Reductase

Scientific Reports 9, 19703 (2019). Doi: 10.1038/s41598-019-56145-z. E pub Dec 23 2019

Nanjing_University

BPH (Benign Prostatic Hyperplasia) is so common and discussion about its causes is so frequent that we could well expect there to be good options for shrinking prostates back to normal size and restoring normal urination and prostate health. The usual options for BPH treatment are several widely prescribed drugs that work to reduce prostate size but are also associated with a variety of unpleasant side effects. New research shows that the Pao pereira plant extract, famous for its broad-spectrum anti-cancer effect, is an excellent BPH treatment — as good as the drugs — and it doesn’t induce negative side effects. The study was conducted at Nanjing University under the direction of Dr. Jun Yan.

The key is a newly discovered modulating effect of the Pao extract on enzymatic pathways that promote the development of BPH. The new paper is entitled “Pao Pereira Extract Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by Regulating 5a-reductase”. The critical enzyme pathway is 5a-reductase which converts testosterone to dihydrotestosterone (DHT)—a more active hormone that triggers the proliferation of prostate cells that leads to BPH. By lowering the level of 5alpha-reductase the Pao extract lowers the level of DHT thus removing the trigger for BPH.

The study confirms that the Pao extract suppresses inflammation of the prostate by affecting the hormone imbalance that occurs in older men as testosterone levels drop and 5a-reductase increases the level of DHT. The extract is also effective at halting the overgrowth of BPH cells in the prostate by inducing cell cycle arrest. It also lowers the level of androgen receptor that mediates hormonal induction of BPH and reduces the level of PSA, the well-known marker for prostate inflammation and cancer. And referring to cancer, by lowering prostate inflammation Pao pereira extract lowers the risk of progression to prostate cancer.

The experiments were conducted both in vitro and in vivo and no evidence for side effects were seen. The data indicates that the Pao pereira extract provides an ideal therapeutic response for BPH that can be taken without concern for negative side effects. This new work, together with previous research, shows that Pao pereira is effective against all stages of prostate health problems including chronic inflammation, prostate cancer and advanced prostate cancer.

Abstract

Scientific Reports Pao Pereira Reduces BPH

Benign prostatic hyperplasia (BPH) is one of the most common diseases in the urinary system of elderly men. Pao extract is an herbal preparation of the bark of the Amazon rainforest tree Pao Pereira (Geissospermum vellosii), which was reported to inhibit prostate cancer cell proliferation. Herein we investigated the therapeutic potential of Pao extract against BPH development in a testosterone-induced BPH rat model. The administration of testosterone induced the prostate enlargement, compared with the sham operated group with vehicle treatment. The BPH/Pao group showed reduced prostate weight comparable with BPH/finasteride group. Notably, Pao treatment did not significantly reduce body weights and sperm number of rats, compared with the control group. Furthermore, Pao extract treatment reduced the proliferative index in prostate glands and testosterone-induced expression levels of AR, as well as androgen-associated proteins such as SRD5A1 and PSA. Moreover, Pao extract and its active component, flavopereirine, induced cytotoxicity on human prostate epithelial RWPE-1 cells in a dose- and time- dependent manner with G2/M arrest. Consistently, Pao extract and flavopereirine suppressed the expression levels of SRD5A1, AR and PSA, respectively. Together, these data demonstrated that Pao extract suppresses testosterone-induced BPH development through inhibiting AR activity and expression, and suggested that Pao extract may be a promising and relative safe agent for BPH Treatment.

BPH Treatment & Pao Pereira Data

BPH Treatment Pao Pereria

The figure above shows the effects of Pao extract on rat prostate. (a) Schematic presentation of experimental procedure. Sham group as control group: After sham operation, rats were treated with i.p. injection of corn oil and oral saline; BPH/Veh group: After castration, rats were i.p. injection of 5 mg/kg testosterone propionate (TP) daily and were intragastric administrated with saline; BPH/FN (Finasteride) and BPH/Pao groups: After castration, rats were i.p. injection of 5 mg/kg TP and intragastic administration of finasteride (10 mg/kg) or Pao extract (20 mg/kg) daily for 28 days, respectively. (b) The representative photos of the dissected prostate glands from four groups. (c) The weight of whole prostate without urethra. (d) The changes in the rat prostate index of four groups. (e) Effect of Pao extract on body weight. n = 5; **p < 0.01; ***p < 0.001.

BPH Treatment Pao Pereria Figure 2

The figure above shows the histopathological analysis of the prostate tissues in the testosterone-induced BPH rats after being treated with Pao extract. (a) H&E staining of the sham control, BPH/Veh, BPH/FN and BPH/Pao groups. The sections were photographed by microscope. The scale bars in photos above are 50 μm and in photos below are 20 μm. (b) Quantification of the thickness of epithelial layers; (c) quantification of the fold changes of the lumen areas among four groups. ***p < 0.001.


Benign prostatic hyperplasia (BPH) is one of the most common forms of chronic inflammation in the urinary system of older men. We investigated the therapeutic potential of Pao Pereira extract against BPH development in a testosterone-induced BPH rat model. The administration of testosterone induced the prostate enlargement and either Pao extract or finasteride was evaluated for potential to resolve the BPH condition. Results showed that prostate weights were dramatically reduced in both the Pao and finasteride groups. Notably, Pao treatment did not significantly reduce sperm numbers which is a well-known side effect of finasteride. Pao extract was found to suppress testosterone-induced BPH development by inhibiting androgen receptor expression and activity and by reducing expression of 5α-reductase and Prostate Specific Antigen (PSA). Pao Pereira extract may be a promising and relatively safe agent for BPH.

charles m cancer testimonial headshot

Evidence of a drop in PSA levels

Long-time friend with a person who worked alongside Professor Mirko Beljanski, my wife and I support The Beljanski Foundation, which works for the rehabilitation of this great scientist.

Following a visit to my physician, we learned my PSA levels were "6.10" (I was 71 years old at the time).

Nothing to worry about in his opinion as long as my PSA levels did not continue to raise. If they did, I would be diagnosed with prostate cancer. I did not want to leave anything to chance, so I set up a preventive treatment with Rauwolfia vomitoria (ROVOL V). See the chart below for my results.

Since then my PSA levels have been great and as for my attending physician, we have not had to talk about prostate cancer ever again :)

Charles M

Rising PSA levels headshot

Rising PSA levels

As someone generally concerned about my health, I visit my doctor regularly. After a check up in 1991, my doctor was concerned with the results from my blood tests. They required additional examinations and, in particular, an ultrasound of my prostate, which showed my PSA levels were up.

After learning this I decided and asked my doctor to tell me how much Rauwolfia vomitoria I should take. Thanks to this good prevention reflex, everything quickly returned to order and there were no other prostate alerts. My PSA levels returned to normal and I am relatively healthy. My health is good and I consider that the Rauwolfia vomitoria extract researched by Dr. Beljanski to be my saving grace.


Peter's Testimonial headshot

Peter's Testimonial

Prostate fatigue?

My partner complained four years ago of unpleasant and disabling sensations: he got up frequently at night to go to the bathroom, and during the day he had frequent and irresistible urges to urinate, without being able to hold back.

We talked about it together and knowing well the Beljanski extracts, and the clinical trials in the USA on men with a high PSA levels but without declared prostate cancer, I recommended the Beljanski extracts to him.

He then took Pao pereira and Rauwolfia vomitoria in morning and evening. The symptoms quickly subsided and after 15 days he was no longer in discomfort. He continued the taking the extracts for 1 month. It was not enough for my taste, but hey, it's his call.

The following year, the unpleasant sensations reappeared. He then resumed the same treatment at the same doses, and with the same result. He agreed to continue using the extracts for a little longer this time.

I hope the effects of the treatments will last longer.

It is very reassuring to have such effective products at your disposal.

So gentlemen, don't wait until you have prostate cancer to address this issue! Your body can give you give signs of weakness and warning signals of a more serious dysfunction or quite simply of aging of the organ. Beljanski's extracts are really effective in both cases, and the result can be seen very quickly.

My partner has been able to avoid any serious illness thanks to these extracts.


headshot Rod W testimonial

Rod W.

“I’m a poster child for Beljanski’s botanicals. I feared the worst when my doctor told me that I had a PSA count of 19. My doctor told me it was almost certainly prostate cancer, and it had probably metastasized. I found out about these botanicals through the book Winning The War On Cancer: The Epic Journey Towards a Natural Cure. I was skeptical, but I took them. Six weeks later my PSA count was down to 7. Then then it slipped to 5 and has stayed there for over a year.”

– Rod W. from Denver, CO

Rod W.