Publications on cancer stem cells
Publications on Cancer Stem Cells
Pancreatic cancers are enriched with cancer stem-like cells (CSCs), which are resistant to chemotherapies, and responsible for tumor metastasis and recurrence. We investigated the extract of a medicinal plant Pao pereira for its activity against pancreatic CSCs. Pao inhibited overall proliferation of human pancreatic cancer cell lines and had limited cytotoxicity to normal epithelial cells. In several assays pancreatic CSC population was significantly reduced. In vivo, the Pao extract significantly reduced tumorigenicity of PANC-1 cells. Further investigation is warranted in using Pao as a novel treatment targeting pancreatic CSCs.
The poor treatment outcomes of pancreatic cancer are linked to an enrichment of cancer stem cells (CSCs) in these tumors, which are resistant to chemotherapy and promote metastasis and tumor recurrence. In these experiments, the pancreatic CSC population, identified using cell surface markers or a tumor spheroid formation assay, was significantly reduced by the Rauwolfia vomitoria extract. In vivo the Rauwolfia extract significantly reduced the tumorigenicity of pancreatic cancer cells. Taken together, these data showed that Rauwolfia preferentially inhibited pancreatic cancer stem cells.
Cancer stem cells are a type of stem cell specific to cancer, that is able to reproduce through self-renewal and regeneration into new tumor cells. Cancer stem cells are thought to survive chemotherapy treatments and provide the basis for tumor regrowth. It is critical to find treatments for cancer stem cells to prevent this disease from resurfacing in a person again and again. Research conducted at Kansas University Medical Center concluded that both the Pao pereira (Pau pereira) and Rauwolfia vomitoria extracts inhibited the proliferation of multiple human ovarian cancer cell lines in vitro.
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*Extract of the Medicinal Plant Pao Pereira Inhibits Pancreatic Cancer Stem-Like Cell In Vitro and In Vivo
Pancreatic cancers are enriched with cancer stem-like cells (CSCs), which are resistant to chemotherapies, and responsible for tumor metastasis and recurrence. We investigated the extract of a medicinal plant Pao pereira for its activity against pancreatic CSCs. Pao inhibited overall proliferation of human pancreatic cancer cell lines and had limited cytotoxicity to normal epithelial cells. In several assays pancreatic CSC population was significantly reduced. In vivo, the Pao extract significantly reduced tumorigenicity of PANC-1 cells. Further investigation is warranted in using Pao as a novel treatment targeting pancreatic CSCs.
Pancreatic cancers are enriched with cancer stem-like cells (CSCs), which are resistant to chemotherapies, and responsible for tumor metastasis and recurrence. We investigated the extract of a medicinal plant Pao pereira for its activity against pancreatic CSCs. Pao inhibited overall proliferation of human pancreatic cancer cell lines and had limited cytotoxicity to normal epithelial cells. In several assays pancreatic CSC population was significantly reduced. In vivo, the Pao extract significantly reduced tumorigenicity of PANC-1 cells. Further investigation is warranted in using Pao as a novel treatment targeting pancreatic CSCs.
*Inhibition of pancreatic cancer stem cells by Rauwolfia vomitoria extract
The poor treatment outcomes of pancreatic cancer are linked to an enrichment of cancer stem cells (CSCs) in these tumors, which are resistant to chemotherapy and promote metastasis and tumor recurrence. In these experiments, the pancreatic CSC population, identified using cell surface markers or a tumor spheroid formation assay, was significantly reduced by the Rauwolfia vomitoria extract. In vivo the Rauwolfia extract significantly reduced the tumorigenicity of pancreatic cancer cells. Taken together, these data showed that Rauwolfia preferentially inhibited pancreatic cancer stem cells.
The poor treatment outcomes of pancreatic cancer are linked to an enrichment of cancer stem cells (CSCs) in these tumors, which are resistant to chemotherapy and promote metastasis and tumor recurrence. In these experiments, the pancreatic CSC population, identified using cell surface markers or a tumor spheroid formation assay, was significantly reduced by the Rauwolfia vomitoria extract. In vivo the Rauwolfia extract significantly reduced the tumorigenicity of pancreatic cancer cells. Taken together, these data showed that Rauwolfia preferentially inhibited pancreatic cancer stem cells.
*Extracts of the medicinal plants Pao pereira and Rauwolfia vomitoria inhibit ovarian cancer stem cells in vitro
Cancer stem cells are a type of stem cell specific to cancer, that is able to reproduce through self-renewal and regeneration into new tumor cells. Cancer stem cells are thought to survive chemotherapy treatments and provide the basis for tumor regrowth. It is critical to find treatments for cancer stem cells to prevent this disease from resurfacing in a person again and again. Research conducted at Kansas University Medical Center concluded that both the Pao pereira (Pau pereira) and Rauwolfia vomitoria extracts inhibited the proliferation of multiple human ovarian cancer cell lines in vitro.
Cancer stem cells are a type of stem cell specific to cancer, that is able to reproduce through self-renewal and regeneration into new tumor cells. Cancer stem cells are thought to survive chemotherapy treatments and provide the basis for tumor regrowth. It is critical to find treatments for cancer stem cells to prevent this disease from resurfacing in a person again and again. Research conducted at Kansas University Medical Center concluded that both the Pao pereira (Pau pereira) and Rauwolfia vomitoria extracts inhibited the proliferation of multiple human ovarian cancer cell lines in vitro.
PSA levels went from 17.75 to 0.2 in three months
I had 40 radiotherapy sessions. The oncologist said, "I'm 95% out of here." So 5% of the cancer remained in my body and it seemed aggressive. I decided to see another doctor and I went to Bordeaux. In Bordeaux I was told that indeed there were more tests to be done. So I changed my oncologist to the oncologist in Bordeaux and continued my treatment. After the radiotherapy they put me on casodex, then on an injection of hormones that made me gain weight.
But I was still not cured, as the 5% of cancer that was left came back with a vengeance. Three months after the radiotherapy, my doctor wanted to put me on chemo.
My sister-in-law gave me the name of Doctor Beljanski and then I did my own research. After having read the information available on beljanski.org, I contacted a person who had a similar issue. He listened to me, guided me and put me in touch with a doctor familiar with the Beljanski Approach. I ordered the extracts, and decided to get away and said “I'm going to Morocco for three months”. I am lucky to have a vacation home, I went to Morocco for three months with the extracts. I only had one casodex tablet to take per day and the Beljanski extracts which I started initially on my way to Morocco. I had 17.75 for my PSA levels at the time. I did my three months in Morocco, I visited Morocco… I came back from Morocco, I did my blood tests, I went back to Bordeaux: I had 0.2 PSA. From 17.75 I went down to 0.2 in three months.
What did my oncologist say at the time?
So my oncologist said to me, “I don't understand. What is happening? I don't understand. It's just casodex."
After that he gave me an injection every three months and made me stop casodex. But he didn't understand why my PSA levels diminished like this. So I finally told him what I was really doing. He smiled and told me "I know". I asked "What do you think?" and he replied, "I am not allowed to talk about it, but if it makes you feel good, take it, it cannot harm you". And we stayed there.
I especially thank doctor Beljanski for his work because it is true and sad to say that in France our government is still not encouraging this type of medicine.
