*Extract of the Medicinal Plant Pao Pereira Inhibits Pancreatic Cancer Stem-Like Cell In Vitro and In Vivo
December
2018
"Extract of the Medicinal Plant Pao Pereira Inhibits Pancreatic Cancer Stem-Like Cell In Vitro and In Vivo." by Ruochen Dong, Ping Chen and Qi Chen
Pancreatic cancers are enriched with cancer stem-like cells (CSCs), which are resistant to chemotherapies, and responsible for tumor metastasis and recurrence. We investigated the extract of a medicinal plant Pao pereira for its activity against pancreatic CSCs. Pao inhibited overall proliferation of human pancreatic cancer cell lines and had limited cytotoxicity to normal epithelial cells. In several assays pancreatic CSC population was significantly reduced. In vivo, the Pao extract significantly reduced tumorigenicity of PANC-1 cells. Further investigation is warranted in using Pao as a novel treatment targeting pancreatic CSCs.
Read more…Read the full publication
View this publication's details
View this publication's details
