Publications melanoma

Publications on Melanoma


Melanoma

Melanoma

History


Melanoma is the most serious skin cancer. If it is not diagnosed and treated early, it is lethal because current treatments don’t work (Figure 1). Predictions from the National Cancer Research Institute (London, UK) show steep increases in the incidence of melanoma among women and even more so among men (Figure 2) There is an urgent need for more effective therapies.

Although the anti-cancer effects of Pao pereira and Rauwolfia vomitoria (killing cancer cells) have already been largely established, a new combination of tea and Ginkgo extracts promises synergistic anti-melanoma efficacy.

Figure 1

melanoma

Figure 2

melanoma

Recent breakthroughs in Melanoma Research

Yes, this is not a typo! The Beljanski Foundation is pleased to share TWO significant breakthroughs in the fight with melanoma, thanks to promising new approaches coming from research at Kansas University Medical Center, which was sponsored by The Beljanski Foundation: First, extracts of a combination of four green teas inhibit the growth of several cancer cell lines, including melanoma cancer cells. And second: Beljanski’s Golden Leaf Ginkgo extract has the potential to inhibit melanoma progression by limiting blood supply that feeds the tumor. What is more: this exciting anti-cancer mechanism is expected to work for melanoma and many other cancers including lymphoma, breast and pancreatic.

PAO PEREIRA AND RAUWOLFIA VOMITORIA INHIBIT THE GROWTH OF SEVERAL CANCER CELL LINES

Beljanski tested his Pao extract on sixteen different cancer cell lines including malignant melanoma cells. The extract selectively destroyed the cancer cells, but did not inhibit normal cell multiplication. Selective action against cancer cells makes the extract nontoxic and safe to use.

NEW

GREEN TEA BLEND: INHIBITING MELANOMA PROLIFERATION

Four green teas were selected by Mirko Beljanski himself, as they showed strong anti-cancer potential in the Oncotest. Extract of this special blend was studied at Kansas University Medical Center. Compared to other green teas commercially available, the OnkoTea blend showed to have broad spectrum anti-cancer cell activity. The results were impressive for melanoma: the tea extract was effective against all four melanoma cell lines tested.
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NEW

GINKGO EXTRACT: REGULATION OF RNASE ENZYMES

Beljanski’s discovery of the radioprotective activity of Golden Leaf Ginkgo extract led him to study its ability to neutralize the activity of various RNAase enzymes associated with skin fibrosis. New research conducted at Kansas University shows that the Golden Leaf Ginkgo extract has also the ability to neutralize the activity of various RNAase enzymes associated with melanoma. These results open a new frontier for the use of Golden Leaf Ginkgo for its potential to starve melanoma by suppressing blood supply to the tumor.

NEW RESEARCH PROJECT TO BE FUNDED


Golden Leaf Gingko extract

UV radiation activates a family of enzymes known as ribonucleases–RNAases– that are associated with fibrosis. An extract from the golden leaf of the Ginkgo tree reduces the activity of these RNAases and helps prevent radiation induced fibrosis. Beljanski found that these hyperactive RNAases are also secreted by melanomas as well as several other cancers.

The golden leaf Ginkgo extract suppresses the activity of RNAases released by melanoma and other cancer cells. Melanoma secretes a growth factor that promotes its own advance. This growth factor, called angiogenin, is the signal that melanoma cells send out to draw new blood vessels that bring nutrients and oxygen enabling melanoma progression. A new study in Dr. Qi Chen’s laboratory is expected to show that the Golden Leaf Ginkgo extract specifically reduces the angiogenin activity released from melanoma cells. The Ginkgo extract has the potential to be a significant new anti-cancer therapeutic that works by suppressing the blood supply to the melanoma.

Will the Ginkgo extract inhibit those enzymes?

Angiogenin is an extremely interesting enzyme because melanoma can secrete this RNase to create a new blood supply for nutrients and oxygen, which allows tumor growth. Inhibition of a specific RNAase enzyme called angiogenin is a longstanding goal in biomedical research, as it would limit tumor advance by starving cancer cells.

Additional studies are needed to confirm this remarkable activity of the Ginkgo extract, and it’s potential to control melanoma and other cancers that use angiogenin to obtain blood. The next step is to examine the affect Ginkgo suppression of angiogenin on the formation of endothelial tubules—an early step in the formation of new blood vessels. These experiments will be conducted in vitro.

Upcoming in vivo studies will also test the benefits of combining the new-found anti-melanoma activity of Ginkgo with Pao pereira, Rauwolfia vomitoria and the green tea extracts.

How can you help fund this research?

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Publications

  • J.E. CAUSSE, T. NAWROCKI, M. BELJANSKI, “Human Skin Fibrosis RNase
    Search for a Biological Inhibitor-Regulator“. Deutsche Zeitschrift für Onkologie,
    26, 5, 1994, pp. 137-139.
  • Ping Chen and Qi Chen. “Effects of Different Tea Products on the Growth of Cancer Cells”. EC Nutrition 14.12 (2019): 01-13.
  • Beljanski S and Hall J. Anti-Cancer Effects of a Combination of Four Green Teas. EC Nutrition 16.2 (2021).  https://www.ecronicon.com/ecnu/pdf/ECNU-16-00904.pdf

The Beljanski Approach to Cancer

Since 1999, The Beljanski Foundation has worked toward a natural cure for cancer. The research has focused on the Pao pereira and Rauwolfia vomitoria plant extracts which have broad spectrum anti-cancer activity and are non-toxic. The Foundation has recently initiated new experiments to study the effect of Golden Leaf Ginkgo extract on a family of overactive enzymes (RNases) that are found in the melanoma environment and in the blood serum of patients with a variety of cancers. Some of these enzymes can help promote cancer cell growth and preliminary data show that the Ginkgo extract specifically inhibits one enzyme (angiogenin) that triggers formation of new blood vessels that feed tumors. Like Pao and Rauwolfia, the Ginkgo extract is non-toxic, but it’s anti-cancer effect works by an independent mechanism. Combination of all three extracts will be a promising strategy for melanoma as well as other cancers that use angiogenin to promote their growth.

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"Beljanski’s Ginkgo biloba is unlike any other conventional plant extract, and so is its application. The unique Ginkgo biloba extract is recommended very strongly to anyone undergoing anti-cancer treatment because disease coupled with conventional treatments work to disrupt normal protein
functioning, which poses a danger for the patient...Without exhibiting any detrimental side effects, the particular extract of Ginkgo biloba invented by Beljanski has proven itself to be beneficial to nearly all patients."

Dr. Morton Walker

Cancer’s Cause, Cancer’s Cure: The Truth about Cancer, Its Causes, Cures, and Prevention. The scientific
discoveries of Mirko Beljanski, PhD

What it says about Ginkgo

“Taken during and after exposure to radiation this specific golden leaf extract of Ginkgo biloba protects, prevents and even reverses (which to some means “heals”) the fibrosis caused by excessive radiation, and brings patients’ plasma RNase activity back to normal. In my father’s laboratory the extract turned out to do just as well as WR-2721, without the side effects. Beljanski published his results, but by then the Berlin Wall had fallen and military officials had lost interest in the subject. Nevertheless, several French doctors were quick to see the benefit of a product that supported the healing process after surgery and helped protect against radiation-induced skin fibrosis. They started to ask for it. My maternal grandfather, Pr. Reneì Lucas, was a distinguished scholar, a member of the prestigious Academie des Sciences, and recently retired from his position of Director of the Paris School of Physics and Chemistry as well as Professor of Physics at the Sorbonne. He took it upon himself to scour the city’s municipal parks with a backpack and collect as many leaves as he could in season. My grandmother tagged along, and together they were a very effective pair—until they were caught for stealing leaves!”
P.91 Winning The War On Cancer: The Epic Journey Towards a Natural Cure

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What scientists are saying about Melanoma

Healthy Tuesday About Melanoma
On Demand

Hear directly from
Dr. John Hall and Dr. Qi Chen

Every month at Healthy Tuesdays – virtual events organized to help you Feel Better Naturally – we feature healthcare professionals who come together to share information and advice related to holistic health.

Dr. Qi Chen and Dr. John Hall were the keynote speakers at the Virtual Healthy Tuesdays discussing Melanoma. They shared with the participants their expertise, facts and thoughts.

We invite you to watch the event recording on demand.

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Testimonial: Mary B. and Melanoma

Pao pereira, Rauwolfia vomitoria and Ginkgo helped me with melanoma, the deadliest type of skin cancer. At first I was hoping it was just basal cells (which do not have metastasis), as those are not too dangerous, just unpleasant because it was on my face!

Unfortunately, it was more severe, but thankfully my doctor recommended a combination of chemotherapy and the Beljanski extracts to help me overcome this.

Sincerely, Mary B.


*Superior Anti-Cancer Effect of a New Blend of Green Teas

EC Nutrition 14.12 (2019): 01-13. https://www.ecronicon.com/ecnu/pdf/ECNU-14-00734.pdf

Breakthrough Cancer Research by The University of Kansas Medical Center & The Beljanski Foundation

A research study by The University of Kansas Medical Center analyzing the anti-cancer effects of several well-known teas has shown that OnkoTea®, a newly developed blend of green teas, is most effective at inhibiting the growth of multiple cancer cell lines. This blend combines four different green teas: Ceylon Green, Bi Lou Chun, Organic Gunpowder and Dragonwell.

The anti-cancer potential of each of these four green teas was originally identified by Prof. M. Beljanski of the Pasteur Institute using the Oncotest, an assay he developed for detecting carcinogenic and anti-carcinogenic compounds. The anti-cancer activity of OnkoTea® was compared with the activity of several popular brands of tea including Bigelow, Kusmi and Lipton. The first tests analyzed the activity of OnkoTea® against breast cancer cells including one highly metastatic cell line. OnkoTea® was the best at reducing the number of breast cancer cells.

OnkoTea® also proved to be effective against liver and bladder cancer cells and showed impressive activity against four melanoma skin cancer cell lines.  The data shows the viability of the cancer cell lines after exposure to extracts of each of the teas that were tested with OnkoTea® “showing the best inhibitory effect.”

The studies were conducted in vitro and tested a range of concentrations of the teas (200, 400, 600 and 800 micrograms per milliliter) at 24, 48 and 72 hour time points as shown in the images below. Cancer cell lines tested: Breast MCF-7, Metastatic Breast MDA-MB-231; Liver HepG2, Bladder 5637, Melanoma A375, UACC-257, SK-MEL-2, SK-MEL-5.

 

 

Green teas are known to have anti-cancer benefits, but the new cancer research shows that the activity of OnkoTea® stands out for having the most potent anti-cancer effect.

Current models of carcinogenesis—how cancer starts—tell us that a gradual, but persistent exposure to carcinogens in our environment is responsible. Many of these carcinogens get into our cells, bind to our DNA and damage DNA structure. After chronic interactions with carcinogens the DNA is destabilized—no longer structurally healthy, and the two strands of the duplex are sporadically separated, making the cell amenable to the onset of cancer.

But if cancer starts by gradual buildup of DNA destabilization, might gradual consumption of a mix of green teas with relatively potent anti-cancer effect be part of the antidote? It takes years for the DNA damage associated with cancer to develop and the habitual consumption of a tea with documented anti-cancer effect can be part of a prevention strategy.

Abstract

Tea preparations are popular for its anti-oxidant and anti-cancer effects. We want to understand how different tea products could differently affect the growth of cancer cells with heterogeneity. Here we evaluated 4 popular tea products on the growth of multiple cancer cells with different genetic makeovers, including 3 green teas and a black tea, namely Bigelow Tea - Green Tea with Mint (Bigelow), Kusmi Tea - Chinese Green Tea (Kusmi), OnkoTea® - Base Tea Blend (Onko), and Lipton Tea - Lipton Black Tea (Lipton).

Panels of breast cancer cells, melanoma cells, liver cancer cells, and bladder cancer cells were tested. The results showed that:

  1. The effects of tea on cell proliferation was concentration dependent. At lower concentrations (< 100 µg/mL), all the 4 tea extracts increased cell viability at 24h treatment. The increase of cell viability diminished, and inhibitory effects was observed as the treatment duration was longer. At a higher concentration range (200 - 800 µg/mL), all 4 tea products inhibited the cancer cells, typically with OnkoTea® showing the best inhibitory effect and Lipton tea the least.
  2. The inhibitory effect was cell line dependent. The melanoma cells A375 cells showed the best sensitivity to the OnkoTea® treatment, which harbors homologous BRAF mutation. The bladder cancer cell line 5637 showed good sensitivity to the tea products, whereas the liver cancer cell line HepG2 was the most resistant of all the tested cells.

Volume 14 Issue 12 December 2019
©All Rights reserved by Ping Chen and Qi Chen

Click here to access the full publication.


Different tea products could affect the growth of cancer cells. Four popular tea products were evaluated, including 3 green teas and a black tea, namely Bigelow Green Tea with Mint, Kusmi Chinese Green Tea, OnkoTea Green Tea Blend, and Lipton Black Tea. Panels of breast cancer cells, melanoma cells, liver cancer cells, and bladder cancer cells were tested. The results showed that the effects of tea on cell proliferation was concentration dependent.  At a higher concentration range, all 4 tea products inhibited the cancer cells, with OnkoTea showing the best inhibitory effect.

*All Green Teas are Not Equal in Anti-Cancer Effect

Results:

The results of a new study comparing the anti-cancer effects of several well-known teas has shown that a newly developed blend of green teas was superior at inhibiting the growth of two breast cancer cell lines, including one highly metastatic cell line. This blend combines four different green teas: Ceylon Green, Bi Lou Chun, Organic Gunpowder and Dragonwell.

Blend of teas selected by Mirko Beljanski

The anti-cancer potential of each of these teas was originally identified by Prof. M. Beljanski of the Pasteur Institute using the Oncotest, an assay he developed for detecting carcinogenic and anti-carcinogenic compounds. The new study confirms the activity of a combination of the four green teas against breast cancer cells.

Green teas have long been associated with anti-oxidant and anti-cancer benefits, but the new research shows that the activity of this specific combination stands out. When tested against other teas including Bigelow®, Kusmi®, and Lipton®, the four green tea blend had the most potent anti-cancer effect on the cultured breast cancer cells. Data in the figure below show the viability of the breast cancer cell lines after exposure to extracts of each of the teas tested (400 micrograms/ml). The green tea blend (OnkoTea®) was the best at reducing the number of breast cancer cells.

OnkoTea and breast cancer

A combination of four green tea extracts that showed anti-cancer potential in the Oncotest proved to inhibit breast, bladder, liver and skin cancer cell proliferation in the Kansas study. It will be interesting to determine whether the measured IC50s in the cell proliferation assays correlate with the level of polyphenols in the different teas and whether the standout results for OnkoTea can be attributed to its polyphenol content.

The results from the Oncotest indicate that the active polyphenols in the green tea extracts, catechins, bind directly to DNA and thereby could exert anti-tumor activity by preventing DNA synthesis in cancer cells. This may well be the mechanism of action for the anti-cancer effects of green teas. There have been several reports of the binding of green tea catechins to DNA. In light of the Oncotest experiment, it will be interesting to determine the chemical affinity of the binding of the tea compounds to normal versus cancer cell DNA.

This approach represents a novel and promising avenue for understanding the health benefits of green tea.

Click here to view the full publication.


A DNA based assay for screening compounds for anti-cancer potential identified four green teas with impressive anti-cancer effect. An extract was prepared from a combination of all four of the teas and this extract was tested for anti-cancer activity in cell based assays in Dr. Qi Chen’s laboratory at the Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center. When tested against extracts of other well-known teas, the four green tea blend had the most potent anti-cancer effect. This research was accepted for presentation at the 16th International Conference of the Society for Integrative Oncology and published in EC Nutrition.

Testimonial: Eliane E. and Melanoma

Testimonial: Eliane E. and Melanoma

Her story and her Melanoma by Dr. Morton Walker

In April, the tiny pimple-like bump on my thigh turned into a nightmare of distress for me. The mole-like tumor was eventually diagnosed as melanoma, a somewhat rare cancer. It required immediate removal. I was hospitalized for diagnostic testing and to ascertain my required cancer markers in order to detect whether any further tumors had developed. Even then, at sixty-two years of age, I was devastated by the thought of early death. I cried everyday as I waited for my results from the surgeon’s skin biopsy. Thus began the story of Eliane E.

The results finally came back. Yes, it was melanoma; I was nevertheless determined to put up a fight.

Melanoma is a cancer that originates in melanocytes, the pigment-producing cells of the skin. Melanocytes ordinarily give skin its distinctive color, but sunlight stimulates them to produce more melanin, the pigment that darkens the skin and increases the risk of a melanoma cancer. The lesion can begin as a new, small, pigmented skin growth on normal skin, most often on sun-exposed areas, or it may develop from preexisting pigmented moles. Sometimes melanoma runs in families. It spreads, or metastasizes, to distant parts of the body where the tumor continues to grow and destroy tissue. It’s not uncommon for the melanoma lesion to appear as a firm black or gray lump as described by Mrs. E.

Chemotherapy is used to treat melanomas that have spread, but few are cured. Some of the people treated live less than nine months; however, the course of the disease varies greatly and depends in part on the strength of the body’s immune defenses. Mrs. E. was one of the fortunate few whose immune ability was receptive to outside help, specifically to the group of correctives that had been developed by Mirko Beljanski, Ph.D. This melanoma victim went on to explain how Beljanski’s products came into her possession.

One evening, a woman in the hospital who was there as a patient asked if she could speak with me. I agreed, although I had no desire to talk about the disease that was ruining my life,” continued Mrs. E. “Yet, it seemed as if fate had sent this person just in time to lift my spirits. The woman told me of her own mother, who also was given a death sentence by her oncologists and yet lives in full health thanks to Dr. Mirko Beljanski’s herbal supplements. Beljanski was deceased by then. Having never heard of him or his plant products before, and knowing that this woman would be leaving the hospital the next day, I asked her to give me more specific information. She did so!

Shortly thereafter, I was operated on for melanoma excision. In order to completely eradicate the approximately one-inch long tumor, the surgeon gouged a deep hole on my thigh, the circumference size of a half-grapefruit, with the expectation of performing a skin graft later on. After I was released, I contacted the Beljanski Foundation, where I received contact information for a homeopathic doctor near my home area of France. After consulting the homeopath, I ordered the supplements over the internet, and just forty-eight hours later, I was able to begin my self-treatment.

The homeopath used my weight, 125 lbs., to figure out how many supplements to take. He prescribed nine vegetarian doses per day of the herb Ginkgo biloba to be swallowed over two months and then four doses of each of the other Beljanski products over ten-months time, she told me. Experiencing tremendous suffering from so much invasive surgery—the incision was deep and wide—I was evaluated every other day by a nurse visiting me at home with no other product for treatment except some soap and water. The visiting nurse kept my surgical wound clean and changed its dressing.

Dr. Beljanski’s supplements brought about a startling beneficial effect. My wound healed with such speed that my surgeon couldn’t believe his eyes when finally I visited his office. I tried to tell the doctor that I was taking a dietary supplement for scarring, but he seemed not to care and no one in his clinic believed me. It was the nurse who had been treating me every other day, and who witnessed the favorable progress of my incision, who helped me to understand just how extraordinary—incredible even—the scar’s rapid healing really was,” Mdm. E. continued. “In two months, the incision was completely closed up and I was lucky enough to learn from the doctor that a graft was no longer necessary because I had healed so quickly.

I would like to thank Dr. Beljanski, whom I never knew, and whom the conventional medical community does not wish to recognize. Today I take his supplements as a precaution every spring and fall. Seeing how successfully my wound healed, my husband decided to take Dr. Beljanski’s Ginkgo biloba after he underwent a bladder operation. His incision also healed up quickly. Since then, I have been a member of the CIRIS organization, and I strongly recommend Dr. Beljanski’s anticancer products to anyone who will listen.

Mrs. E.’s testimonial is an example of the type of result one can expect from the use of Beljanski’s herbal extracts. By taking the anticancer botanicals twice yearly, she firmly believes that she keeps the melanoma in remission. Furthermore, whatever the cause of the skin injury (incision, burn, fibrosis, radiation), the yellow leaf powder of Ginkgo biloba herbal medicine extract, prepared according to Dr. Beljanski’s proprietary method, is of the utmost importance for health professionals to know about and for patients to use.

Excerpts from Cancer’s Cause, Cancer’s Cure: The Truth about Cancer, Its Causes, Cures, and Prevention" by Morton Walker.


127 – Human Skin Fibrosis RNase Search for a Biological Inhibitor-Regulator

Deutsche Zeitschrift für Onkologie, 26, 5, 1994, pp. 137-139.

Available in English only.

ABSTRACT: Human skin fibrosis caused by radiotherapy contains very active ribonucleases (RNasas). This is probably connected with the appearance of postradiotherapy fibrosis. We prepared a highly purified extract of Ginkgo biloba golden leaves, which behaves as biological regulator. It normalizes to a large extent the excessive RNase activity in an extract of irridiated human skin cells, but does not affect activity of normal human plasma RNase. This extract may be used for this fibrosis treatment.


ABSTRACT: Human skin fibrosis caused by radiotherapy contains very active ribonucleases (RNasas). This is probably connected with the appearance of postradiotherapy fibrosis. We prepared a highly purified extract of Ginkgo biloba golden leaves, which behaves as biological regulator. It normalizes to a large extent the excessive RNase activity in an extract of irridiated human skin cells, but does not affect activity of normal human plasma RNase. This extract may be used for this fibrosis treatment.