Publications on Prostate Cancer
The tropical shrub, Rauwolfia vomitoria, is a medicinal plant used traditionally to treat a variety of ailments. A bioactive ß-carboline alkaloid, alstonine, present in this extract was previously shown to have anti-cancer activity against cancer cell lines. This study considers the potential anti-prostate cancer activity of this extract in vitro and in vivo. Rauwolfia vomitoria extract standardized for ß-carboline alkaloids was tested for ability to influence the growth and survival of the human LNCaP prostate cancer cell line. A WST-1 assay was used to measure cell growth, and cell cycle analyses were conducted with flow cytometry. Western blot detection of PARP cleavage and accumulation of cells containing subgenomic DNA indicated induction of apoptosis. Pathway specific microarray analyses were utilized to identify the effect of Rauwolfia extract on the expression of 225 genes. Mice xenografted with LNCaP cells were treated with the extract or placebo control, and tumor growth was measured for 5 weeks.
HEALTHY TUESDAY ABOUTPROSTATE AND OVARIAN CANCERON DEMAND
Hear directly fromDr. John Hall and Dr. Leigh Erin Connealy, MD
Every month at Healthy Tuesdays – virtual events organized to help you Feel Better Naturally – we feature healthcare professionals who come together to share information and advice related to holistic health.
In honor of Prostate and Ovarian Cancer Awareness Month, this Healthy Tuesdays event featured Dr. John Hall and Dr. Leigh Erin Connealy, MD, experts in integrative medicine. Our speakers shared information and answered questions about the latest ways to naturally prevent, treat and beat Prostate and Ovarian Cancer.
We invite you to watch the event recording on demand.
