Follow us on: Facebook Youtube LinkedIn
  • Donate To Research
logo
logo
  • Home
  • Beljanski Legacy
      • Mirko Beljanski
        • History
        • Breakthroughs
        • Beljanski and Cancer
        • Publications
        • Beljanski’s Extracts
      • The Beljanski Foundation & La Fondation Beljanski
        • Mission
        • History
        • Governance
        • Approach to Cancer
        • Research Projects
        • R.G.C.C. Laboratory
        • Annual Report
      • Press
        • Press Mentions and Inquiries
        • Learn More About Sylvie Beljanski
        • Free eBooks
      • Stay Tuned!
      • Books
      • On Demand Events
  • Beljanski Ingredients
      • Pao Pereira
        • Pao Pereira
        • Research
        • Testimonials
        • Monograph
      • Rauwolfia Vomitoria
        • Rauwolfia Vomitoria
        • Research
        • Testimonials
        • Monograph
      • Ginkgo Biloba
        • Ginkgo Biloba
        • Research
        • Testimonials
        • Monograph
      • RNA Fragments
        • RNA Fragments
        • Research
        • Testimonials
        • Monograph
      • Green Teas
        • Green Teas
        • Research
        • Testimonials
      • Stay Tuned!
  • Cancer & More
      • Cancers Pages
        • Prostate Cancer
        • Pancreatic Cancer
        • Ovarian Cancer
        • Breast Cancer
        • Skin Cancer (Melanoma and more…)
        • Cancerous Stem Cells
        • All Cancers
        • Cancer Prevention
      • Other Cancers
        • Colorectal Cancer
        • Cervical Cancer
        • Lung Cancer
        • Brain Cancer
        • Kidney Cancer
        • Lymphoma
        • Leukemia
        • Oral Cancer
        • Animals and Cancer
      • Other pathologies
        • Viruses
        • AIDS
        • Autism
        • COVID-19
        • Benign Prostatic Hyperplasia (BPH)
      • Stay Tuned!
      • All Publications
      • A Natural Approach to Cancer
  • Events
      • All Events
      • On Demand Events
      • Stay Tuned!
  • Podcast
  • Books
      • Books
      • ebooks
  • Testimonials
      • Read the Testimonials
      • Share Your Story
  • Contact Us
  • Donate
  • Search
  • Cart 1
  • Donate To Research

*β-Carboline Alkaloid-Enriched Extract from the Amazonian Rain Forest Tree Pao Pereira Suppresses Prostate Cancer Cells

Spring 2009
Prostate CancerPao Pereira

Bark extracts from the Amazonian rain forest tree Geissospermum vellosii (pao pereira), enriched in B-carboline alkaloids have significant anticancer activities in certain preclinical models. Because of the predominance of prostate cancer as a cause of cancer-related morbidity and mortality for men of Western countries, the research team at Columbia University preclinically tested the in vitro and in vivo effects of a pao pereira extract against a prototypical human prostate cancer cell line, LNCaP. When added to cultured LNCaP cells, pao pereira extract significantly suppressed cell growth in a dose-dependent fashion and induced apoptosis. Immunodeficient mice heterotopically xenografted with LNCaP cells were gavaged daily with pao pereira extract or vehicle control over 6 weeks. Tumor growth was suppressed by up to 80% in some groups compared with tumors in vehicle-treated mice

Prostate cancer is the most frequently diagnosed malignancy in males and a leading cause of cancer deaths in men.6 Given the relatively high frequency with which prostate cancer occurs, prevention offers the most likely means to reduce the health risk to men posed by the disease. If pao pereira bark extract has tumor-suppressing activity for prostate cancer without overt toxicity, one can consider the possibility that it might be used as a preventive agent as a dietary supplement.

Abstract

Bark extracts from the Amazonian rain forest tree Geissospermum vellosii (pao pereira), enriched in β-carboline alkaloids have significant anticancer activities in certain preclinical models. Because of the predominance of prostate cancer as a cause of cancer-related morbidity and mortality for men of Western countries, we preclinically tested the in vitro and in vivo effects of a pao pereira extract against a prototypical human prostate cancer cell line, LNCaP. When added to cultured LNCaP cells, pao pereira extract significantly suppressed cell growth in a dose-dependent fashion and induced apoptosis. Immunodeficient mice heterotopically xenografted with LNCaP cells were gavaged daily with pao pereira extract or vehicle control over 6 weeks. Tumor growth was suppressed by up to 80% in some groups compared with tumors in vehicle-treated mice. However, we observed a striking U-shaped dose-response curve in which the highest dose tested (50 mg/kg/d) was much less effective in inducing tumor cell apoptosis and in reducing tumor cell proliferation and xenograft growth compared with lower doses (10 or 20 mg/kg/d). Although this study supports the idea that a pao pereira bark extract has activity against human prostate cancer, our in vivo results suggest that its potential effectiveness in prostate cancer treatment may be limited to a narrow dose range.

Read the full publication
View this publication's details
Share

Contact us

A member of the Beljanski Foundation team will call you back as soon as possible.

I am a patient, survivor or caregiver

Call me back Put me in touch with a healthcare professional

I am a healthcare professional

Receive documentation or join a webinar

Upcoming Events

Breakthroughs in Natural Cancer Research
Sep
28

Breakthroughs in Natural Cancer Research

September 28, 2025, 1:30 pm - 5:00 pm
Hilton London Euston
Book now

Support cancer research, or become a friend of the Foundation

Our work is made possible thanks to the generous donations of people who believe in the mission of the Beljanski Foundation and believe that the Beljanski Health Approach must be accessible to as many people as possible.

Become a friend of the Foundation Support our research projects

Winning the war on cancer by
Sylvie Beljanski

Buy now

Subscribe to The Beljanski Foundation newsletter

Quick navigation

  • Extracts
    • Pao Pereira
    • Rauwolfia Vomitoria
    • Golden Leaf of Ginkgo Biloba
    • Green Teas
    • RNA Fragments
  • Diseases
    • Breast Cancer
    • Pancreatic Cancer
    • Prostate Cancer
    • Ovarian Cancer
    • Melanoma

Exclusive supplier of Pao Pereira, Rauwolfia Vomitoria, Ginkgo Biloba extracts, Teas, and RNA fragments used by the Beljanski Foundation for scientific research.

Visit Maison Beljanski
Beljanski Legacy
  • Dr. Mirko Beljanski
  • The Oncotest
  • Our Mission
  • Timeline
  • Governance
  • FAQ
Powerful Ingredients
  • Pao Pereira
  • Rauwolfia Vomitoria
  • Golden Leaf of Ginkgo Biloba
  • RNA Fragments
  • Green Teas
Cancer Research
  • All Cancers
  • Prostate Cancer
  • Pancreatic Cancer
  • Ovarian Cancer
  • Breast Cancer
  • Melanoma
  • Cancer Stem Cells
Events & Education
  • The Beljanski Integrative Cancer Conference
  • Upcoming Events
  • On Demand Events
  • Books
  • Continuing Medical Education
  • Healthier You Quiz
The Beljanski Foundation

The Beljanski Foundation, Inc.
Mailing Address:
636 Steamboat Road #4A
Greenwich, CT 06830

Support research
My Account
My account
Follow us on

©2020 The Beljanski Foundation | All Rights Reserved. | Terms of use | Privacy policy Seal of transparency gold Great non profits 2024 top rated Secure Payments, Powered by Stripe

Privacy Preference Center

Privacy Preferences

I am a patient, survivor or caregiver

Get in Touch with UsRequest a Doctor Referral

I am a healthcare professional

Ask a Question or Request InfoApply for a Professional Account

The Beljanski Foundation, Inc.
Mailing Address:
636 Steamboat Road #4A Greenwich, CT 06830
(646) 808 5583

External website disclaimer

You are leaving The Beljanski Foundation Inc. website


You are being directed to a website other than the Beljanski Foundation website. We are not responsible for the content, views, or privacy policies of the third party site. The privacy policy of the third party site may differ from that of The Beljanski Foundation. Click on the button below to proceed to the third party website. If you wish to remain on the Beljanski Foundation website, simply click on the "close" button. Thank you.

Continue to this website

Get a free chapter


    winning the war on cancer audiobook 1200x1200

    Get a free Audiobook chapter


      winning the war on cancer audiobook 1200x1200

      Sign up and be one of the first few to know when the next episode releases PLUS get a FREE audiobook chapter of Sylvie’s award-winning book!


      Help us fight cancer

      Become a “Friend of the Foundation”

      Make an annual donation of $50 or more and become a “Friend of the Foundation”

      What are your advantages as a Friend of the Foundation?

      • You assure scientific researchers the means to make even more progress against cancer
      • Receive 5% off all purchases from Maison Beljanski for a year
      • Twice a year you receive an e-newsletter covering special research
      • You receive information on all events, real and virtual, organized by the Foundation and our Partners In Health
      • You receive information on all promotions offered by Maison Beljanski / Natural Source

      You will become a “Friend of the Foundation” once you have contributed 50 dollars or more in donations. Donations can be made in several installments and are cumulative. Your benefits as a “Friend of the Foundation” are triggered as soon as the 50 dollars are reached and are valid for one year.

      Become Friend of the Foundation

      External website disclaimer

      You are leaving The Beljanski Foundation Inc. website


      You are being directed to a website other than the Beljanski Foundation website. We are not responsible for the content, views, or privacy policies of the third party site. The privacy policy of the third party site may differ from that of The Beljanski Foundation. Click on the button below to proceed to the third party website. If you wish to remain on the Beljanski Foundation website, simply click on the "close" button. Thank you.

      Continue to this website