*Pao Pereira extract suppresses benign prostatic hyperplasia by inhibiting inflammation-associated NFκB signaling
May
2020
Dong Y, Liu J, Xue Z, Sun J, Huang Z, Jing Y, Han B, Shen B, Yan J and Huang R. Pao Pereira extract suppresses benign prostatic hyperplasia by inhibiting inflammation-associated NFκB signaling. BMC Complementary Medicine and Therapies volume 20, Article number: 150 (2020).
Benign prostatic hyperplasia (BPH) is a non-malignant enlargement of the prostate gland, common in older males, that causes urinary and quality of life problems. In a previous study we found that the Pao pereira extract can attenuate BPH development in a rat model by reducing expression of androgen receptor and 5α-reductase. In this study we looked further into the molecular mechanism of Pao pereira’s anti-inflammatory effect in BPH. We found the Pao extract suppressed the growth of two BPH cell lines: BPH-1 and WPMY-1 by inducing apoptosis via inhibition of the NFκB signaling pathway. These findings suggest that Pao Pereira extract may be a very promising therapeutic for BPH.
View this publication's details
View this publication's details
