Authors : DONADIO, R. LORHO, J.E. CAUSSE, T. NAWROCKI, M. BELJANSKI
Deutsche Zeitschrift für Onkologie, 23, 2, 1991, pp. 33-35.
Available in French only
ABSTRACT: Assays were carried out with short-chain RNA fragments in order to determine whether they can prevent or decrease chemotherapy-induced neutropenia and thrombopenia, as well as to evaluate side effects. We studied both first patients, 65 and 77 years old with non-Hodgkin lymphoma. The short-chain RNAs, administred bysublingual way every second day, appear useful in this indication. Neutrophils and platelets are significantly increased. In addition, tolerance of the RNA fragment is good and no side effect is observed. Chemotherapy protocols could be followed without treatment.