Authors : L. LE GOFF, M. BELJANSKI
IRCS Med. Sci., 11, 1983, pp. 363-364.
Available in English only
ABSTRACT: Tumor promoters accelerate the proliferative capacity of tumor cells although at high concentrations they may induce carcinogenesis in animals. Recently it was shown that TPA, (12-0)trtradecanoyl-phorbol-13-acetate), the tumor promoting phorbol ester, appears to act in a similar fashion on normal embryonal diploid and cancer cells. TPA induces differentiation of leukemic cells, activetes silent genes for specific r-RNA synthesis in hybrid cells and promotes cell proliferative capacity or phenotypic cellular changes. Here we report the in vitro effect of TPA on DNA secondary structure and DNA in vitro synthesis.97 - Tumor promoter (TPA), DNA chain opening and unscheduled DNA synthesis