The Beljanski Foundation Fall Newsletter

This year again scientists from all over the world have taken an interest in the natural extracts developed by Dr. Mirko Beljanski. Three new studies refer to his work, and confirm the anti-cancer activity of the plants he studied, all in extremely different areas. A new study confirms the Pao pereira (Pau pereira) extract inhibits chronic prostate inflammation. The prostate tends to enlarge and cause  potentially serious urinary problems. This condition is called BPH (Benign Prostate Hyperplasia). Millions of men suffer from it, and conventional medicine does not offer a definitive cure without side effects.
The study was conducted at Nanjing University (1), and carried out with the support of The Beljanski Foundation and CIRIS, using extracts offered by Maison Beljanski/Natural Source. It shows that Pao pereira (Pau pereira) inhibits excess NFKB activity, helping to reduce the production of inflammatory cytokines. In addition, Pao pereira (Pau pereira) induces apoptosis, also known as the ”cell death program”, of the epithelial cells and stromal cells which are inflamed. This study complements previous publications showing that Pao pereira (Pau pereira) is effective on prostate cancer cells (2), and even on metastasized cancer cells that no longer respond to hormonal treatments (3). All of these publications on the prostate therefore confirm that thanks to its multiple mechanisms of action, Pao pereira (Pau pereira) is effective at all stages of prostate disease (inflammation, cancer, advanced cancer), without toxicity and without side effects. Another study investigates the inhibition of colorectal cancer cells by the Pao pereira (Pau pereira) extract (4). The authors of the study first note the lack of effectiveness of conventional therapies in colorectal cancer, which they attribute in part to the fact that chemotherapy and radiotherapy induce a mutation and destruction of the p53 protein (5). P53 is essential because it is involved in DNA/protein transcription phases, and in the expression of genes which are responsible for repairing cellular damage. Noting, on the other hand, the effectiveness already noted by Dr. Mirko Beljanski of the Pao pereira (Pau pereira) extract on the selective destruction of colorectal cancer cells without affecting healthy cells (6,7), the researchers looked at the mechanism of action of the extract. This new study confirms that the regulatory action of flavoperin (an active molecule of Pao pereira extract) promotes the expression of p53, induces apoptosis in cancer cells, while inhibiting the proliferation of cancer cells (inhibition of JAKs – STATs). Finally, The University of Kansas Medical Center (USA) has just published a study comparing several famous teas with a new blend of green teas called ”OnkoTea®”, which is a blend of organic teas selected by Dr. Mirko Beljanski (8). Green teas have long been associated with antioxidant and anti-cancer benefits, and all teas tested showed some inhibitory effect on cancer cell lines, but OnkoTea® exhibited the best inhibitory effect. Compared to Bigelow®, Kusmi® and Lipton®, OnkoTea® had the strongest anti-cancer effect on breast, liver, bladder and melanoma cancer cells. It therefore seems that this OnkoTea®, like Pao pereira (Pau pereira), is effective on various lines of cancer cells. A second study, specifically targeting activity on melanoma with OnkoTea®, is underway.

References

  1. Dong Y, Liu J, Xue Z, et al. Pao Pereira extract suppresses benign prostatic hyperplasia by inhibiting inflammation-associated NFκB signaling. BMC Complement Med Ther. 2020;20(1):150. Published 2020 May 16. doi:10.1186/s12906-020-02943-2  (https://dx.doi.org/10.1186%2Fs12906-020-02943-2)
  2. Bemis DL, Capodice JL, Desai M, Katz AE, Buttyan R. ß-Carboline Alkaloid-Enriched Extract from the Amazonian Rain Forest Tree Pao Pereira Suppresses Prostate Cancer Cells. Journal of the Society for Integrative Oncology, 2009;7(2):59-65. doi:10.2310/7200.2009.0009  (https://pubmed.ncbi.nlm.nih.gov/19476740/)
  3. Chang C, Zhao W, Xie B, et al. Pao Pereira extract suppresses castration-resistant prostate cancer cell growth, survival and Invasion through inhibition of NFkB signaling. Integrative Cancer Therapies, 2013;13(3):249-258. doi:10.1177/1534735413510557  (https://pubmed.ncbi.nlm.nih.gov/24287876/)
  4. Li JM, Huang YC, Kuo YH, et al. Flavopereirine Suppresses the Growth of Colorectal Cancer Cells through P53 Signaling Dependence. Cancers (Basel). 2019;11(7):1034. Published 2019 Jul 22. doi:10.3390/cancers11071034  (https://dx.doi.org/10.3390%2Fcancers11071034)
  5. Skinner HD, Sandulache VC, Ow TJ, et al. TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence. Clin Cancer Res. 2012;18(1):290-300. doi:10.1158/1078-0432.CCR-11-2260  (https://pubmed.ncbi.nlm.nih.gov/22090360/)
  6. Beljanski M, Beljanski MS. Selective inhibition of in vitro synthesis of cancer DNA by alkaloids of beta-carboline class. Exp Cell Biol. 1982;50(2):79-87. doi:10.1159/000163131  (https://pubmed.ncbi.nlm.nih.gov/7075859/)
  7. Beljanski M. The anticancer agent PB-100, selective active on malignant cells, inhibits multiplication of sixteen malignant cell lines, even multidrug resistant. Genet. Mol. Biol. 2000;20:29–33. doi: 10.1590/S1415-47572000000100005  (http://dx.doi.org/10.1590/S1415-47572000000100005)
  8. Chen P, Chen Q. Effects of Different Tea Products on the Growth of Cancer Cells. EC Nutrition 14.12 (2019): 01-13  (https://www.beljanski.org/wp-content/uploads/2023/05/TEA-GROWTH-K-CELLS-EC-Nutrition-Kansas-2019.pdf)