First published in December 2011 as Chapter 6. “DNA Destabilization, Cancer and Inflammation” Anti-Aging Therapeutics Volume XIII, 53-64
For many years the central paradigm of cancer research has been that specific mutations in a critical set of regulatory genes cause the disease. The mutational theory of cancer has been such a gripping paradigm that alternative explanations for carcinogenesis have been slow to develop and gain attention. This paper will introduce an alternative theory of cancer – the theory of DNA destabilization.